Expression and release of LAG‐3‐encoded protein by human CD4+ T cells are associated with IFN‐γ production

@article{Annunziato1996ExpressionAR,
  title={Expression and release of LAG‐3‐encoded protein by human CD4+ T cells are associated with IFN‐$\gamma$ production},
  author={Francesco Annunziato and Roberto Manetti and I Zorica Tomasevic and Maria Grazia Giudizi and Roberta Biagiotti and Valeria Giann{\`o} and Patrizia Germano and Carmelo Mavilia and Enrico Maggi and Sergio Romagnani},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={769 - 775}
}
The lymphocyte activation gene (LAG) ‐3 is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. In this work, the possibility that LAG‐3 expression by human CD4+ T cells was preferentially related to one or another phenotype of cytokine secretion was investigated. Surface LAG‐3 expression correlated with IFN‐γ, but not IL‐4, production in antigen‐stimulated T cells and it was up‐ regulated by IL‐12. Most activated CD4+ T cell clones with… Expand
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