Expression and regulation of vascular endothelial growth factor in osteoblasts.

  title={Expression and regulation of vascular endothelial growth factor in osteoblasts.},
  author={Shun-ici Harada and Sevgi B. Rodan and Gideon A. Rodan},
  journal={Clinical orthopaedics and related research},
Bone formation is linked closely to angiogenesis. Because prostaglandin E2 (PGE2) is a potent stimulator of bone formation, its effects were evaluated on vascular endothelial growth factor, a secreted endothelial cell-specific mitogen, and a potent angiogenic protein. Prostaglandin E2 increased vascular endothelial growth factor protein in conditioned media of osteoblastic RCT-3 cells within 3 hours. Prostaglandin E2 also increased the steady-state levels of vascular endothelial growth factor… CONTINUE READING


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