Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa.

@article{Papadakis2004ExpressionAR,
  title={Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa.},
  author={Konstantinos Antonios Papadakis and John L. Prehn and Daocheng Zhu and Carol J. Landers and Joanne Gaiennie and Phillip R. Fleshner and Stephan Raoul Targan},
  journal={Inflammatory bowel diseases},
  year={2004},
  volume={10 6},
  pages={
          778-88
        }
}
Chemokine receptors play an important role in the recruitment of activated T cells to inflammatory sites. The aim of this study was to analyze the expression of the chemokine receptor CXCR3 on T lymphocytes in intestinal lymphoid tissues and to document the altered disposition of these cells in patients with inflammatory bowel disease (IBD). The expression and regulation of CXCR3 on mucosal lymphoid tissue and peripheral blood lymphocytes (PBLs) were analyzed by flow cytometry and Northern… CONTINUE READING