Expression and regulation of steroid 5 alpha-reductase 2 in prostate disease.

@article{Silver1994ExpressionAR,
  title={Expression and regulation of steroid 5 alpha-reductase 2 in prostate disease.},
  author={Richard I Silver and Elizabeth Louise Wiley and Duane L. Davis and Anice E. Thigpen and D. W. Russell and John D McConnell},
  journal={The Journal of urology},
  year={1994},
  volume={152 2 Pt 1},
  pages={433-7}
}
The androgen dihydrotestosterone is synthesized by the enzyme steroid 5 alpha-reductase, and it is required for growth and development of the prostate. We used immunohistochemistry to examine the expression of the type 2 isozyme of 5 alpha-reductase in benign prostatic hyperplasia and prostate cancer. The type 2 isozyme is highly expressed within stromal cells in both disease states. No type 2 isozyme is detectable in a lymph node metastasis. Immunoblotting studies show that androgen ablation… CONTINUE READING

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