Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

@article{Purmessur2008ExpressionAR,
  title={Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc},
  author={Devina Purmessur and Anthony John Freemont and Judith A Hoyland},
  journal={Arthritis Research & Therapy},
  year={2008},
  volume={10},
  pages={R99 - R99}
}
INTRODUCTION The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been identified in the human intervertebral disc (IVD) and have been implicated in the mechanisms associated with nerve ingrowth and nociception in degeneration of the IVD. The aim of the current study was to investigate an association between neurotrophin expression in the IVD and the severity of disc degeneration, including the effect of disc-related proinflammatory cytokines on… CONTINUE READING

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