Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.

@article{Reiss2011ExpressionAR,
  title={Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.},
  author={Karina Reiss and Ulf Meyer-Hoffert and Jan J. Fischer and Maria Sperrhacke and Zhihong Wu and O. A. Dimitrieva and Pavel Křenek and S{\'a}rka Suchanov{\'a} and Halka Buryov{\'a} and Rena Brauer and Radislav Sedl{\'a}{\vc}ek},
  journal={Experimental dermatology},
  year={2011},
  volume={20 11},
  pages={
          905-10
        }
}
A balanced proteolytic activity in the epidermis is vital to maintain epidermal homoeostasis and barrier function. Distinct protease-inhibitor systems are operating in different epidermal layers. In the uppermost layer, the stratum corneum, kallikrein-like proteases and their inhibitors are responsible for desquamation of the cornified keratinocytes, thus regulating the integrity of the epidermal barrier. Following discovery and characterisation of the human multidomain inhibitor LEKTI (lympho… CONTINUE READING
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