Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2

@article{Reiss2011ExpressionAR,
  title={Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2},
  author={K. Reiss and U. Meyer-Hoffert and J. Fischer and Maria Sperrhacke and Zhi-hong Wu and O. Dimitrieva and P. Křenek and S. Suchanov{\'a} and H. Buryov{\'a} and R. Brauer and R. Sedl{\'a}{\vc}ek},
  journal={Experimental Dermatology},
  year={2011},
  volume={20}
}
Abstract:  A balanced proteolytic activity in the epidermis is vital to maintain epidermal homoeostasis and barrier function. Distinct protease‐inhibitor systems are operating in different epidermal layers. In the uppermost layer, the stratum corneum, kallikrein‐like proteases and their inhibitors are responsible for desquamation of the cornified keratinocytes, thus regulating the integrity of the epidermal barrier. Following discovery and characterisation of the human multidomain inhibitor… Expand

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