Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.

@article{Vo2013ExpressionAR,
  title={Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.},
  author={Nam Viet Vo and Robert Allen Hartman and Takashi Yurube and Lloydine J. Jacobs and Gwendolyn A. Sowa and James D. Kang},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2013},
  volume={13 3},
  pages={331-41}
}
BACKGROUND CONTEXT Destruction of extracellular matrix (ECM) leads to intervertebral disc degeneration (IDD), which underlies many spine-related disorders. Matrix metalloproteinases (MMPs), and disintegrins and metalloproteinases with thrombospondin motifs (ADAMTSs) are believed to be the major proteolytic enzymes responsible for ECM degradation in the intervertebral disc (IVD). PURPOSE To summarize the current literature on gene expression and regulation of MMPs, ADAMTSs, and tissue… CONTINUE READING