Expression and regulation of complement factors H and I in rat and human cells: some critical notes.

@article{Schlaf2001ExpressionAR,
  title={Expression and regulation of complement factors H and I in rat and human cells: some critical notes.},
  author={Gerald Schlaf and Thorsten Demberg and Nadine Beisel and Henrike L. Schieferdecker and Otto Goetze},
  journal={Molecular immunology},
  year={2001},
  volume={38 2-3},
  pages={
          231-9
        }
}
The complement factors I (FI) and H (FH) are complement regulatory proteins. FI, a highly glycosylated serine protease of 88 kDa cleaves the alpha-chains of both complement components C3b and C4b, thereby inactivating them. Complement FH, a glycoprotein of 150 kDa which is composed of 20 short consensus repeats synergizes with FI by increasing the affinity of FI for C3b in the C3b/FH complex by about 15-fold as compared to free C3b. Furthermore, FH prevents factor B from binding to C3b and… CONTINUE READING
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