Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells.

@article{Brandenburg2009ExpressionAR,
  title={Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells.},
  author={Lars-Ove Brandenburg and Deike J. Varoga and Nicoletta Nicolaeva and Stephen L Leib and Rainer Podschun and Christoph Jan Wruck and Henrik Wilms and Ralph Lucius and Thomas Pufe},
  journal={Journal of neuroimmunology},
  year={2009},
  volume={217 1-2},
  pages={55-64}
}
Bacterial meningitis is characterized by an inflammation of the meninges and continues to be an important cause of mortality and morbidity. Meningeal cells cover the cerebral surface and are involved in the first interaction between pathogens and the brain. Little is known about the role of meningeal cells and the expression of antimicrobial peptides in the innate immune system. In this study we characterized the expression, secretion and bactericidal properties of rat cathelin-related… CONTINUE READING