Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia.

@article{Funghi2016ExpressionAR,
  title={Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia.},
  author={Lucia Funghi and Francesco Damiani and C F Yen and C L Lee and Annalia Lombardi and Frederick Schatz and Charles Joseph Lockwood and Paola Marcolongo and Felice Petraglia and Felice Paolo Arcuri},
  journal={Molecular and cellular endocrinology},
  year={2016},
  volume={437},
  pages={163-170}
}
Glucocorticoids are implicated in successful blastocyst implantation, whereas alterations in glucocorticoid levels are associated with various pregnancy disorders including preeclampsia. Tissue concentration of active glucocorticoids depends on the expression of 11β-hydroxysteroid dehydrogenase (11β-HSD). This study investigated the contribution of first… CONTINUE READING