Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.

@article{Rauz2001ExpressionAP,
  title={Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.},
  author={Saaeha Rauz and Elizabeth Ann Walker and Cedric H. L. Shackleton and Martin Hewison and P. I. Murray and P. M. Stewart},
  journal={Investigative ophthalmology & visual science},
  year={2001},
  volume={42 9},
  pages={2037-42}
}
PURPOSE The human eye is an important target tissue for steroid hormones, and glucocorticoids have been implicated in the pathogenesis of ocular disease, including glaucoma. In peripheral tissues, corticosteroid hormone action is regulated at a prereceptor level through the activity of the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) isozymes: an oxo-reductase (11 beta-HSD1) that activates cortisol (F) from cortisone (E) and a dehydrogenase (11 beta-HSD2) that inactivates F to E. The… CONTINUE READING