Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma.

@article{Dong2016ExpressionAP,
  title={Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma.},
  author={Min Dong and Hai-yan Wang and Xiao-xiao Zhao and Jian-ning Chen and Yi-wang Zhang and Yan Huang and L. Q. Xue and Hai-gang Li and Hong Du and Xiang-yuan Wu and Chun-kui Shao},
  journal={Human pathology},
  year={2016},
  volume={53},
  pages={25-34}
}
As a special subtype of gastric carcinoma, Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) has distinct clinicopathological features. The Cancer Genome Atlas Research Network revealed that EBVaGC also has distinct molecular features: PIK3CA mutations, DNA hypermethylation, and JAK2, PD-L1, and PD-L2 amplification. Here, we evaluated PIK3CA, JAK2, PD-L1, and PD-L2 expression in 59 EBVaGC and 796 EBV-negative gastric carcinoma (EBVnGC) cases using immunohistochemistry and found… CONTINUE READING