Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma.

@article{Ke2009ExpressionAP,
  title={Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma.},
  author={Qing Qing Ke and Juling Ji and Chun Cheng and Yixin Zhang and Mudan Lu and You Min Wang and Li Zhang and Peng Li and Xiaopeng Cui and Li Chen and Song He and Aiguo Shen},
  journal={Experimental and molecular pathology},
  year={2009},
  volume={87 3},
  pages={
          167-72
        }
}
OBJECTIVES Spy1 is a novel cell cycle regulatory gene, which can control cell proliferation and survival through the atypical activation of cyclin-dependent kinases. Recent studies suggested that deregulation of Spy1 expression plays a key role in oncogenesis. To investigate the potential roles of Spy1 in hepatocellular carcinoma (HCC), expression of Spy1 was examined in human HCC samples. METHODS Immunohistochemistry and Western blot analysis was performed for Spy1 in 61 hepatocellular… CONTINUE READING
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