Expression and potential roles of pregnane X receptor in endometrial cancer.

  title={Expression and potential roles of pregnane X receptor in endometrial cancer.},
  author={Hisashi Masuyama and Yuji Hiramatsu and Jun-ichi Kodama and Takafumi Kudo},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={88 9},
Estrogen has been shown to contribute greatly to growth and development in endometrial cancer. And recent research has suggested that intratumoral production of estrogen may play important roles in this cancer tissue. On the other hand, pregnane X receptor (PXR), a new member of nuclear receptors, has been shown to mediate the genomic effects of steroid hormones, including estrogen and xenobiotics. And this receptor is thought to regulate the expression of the cytochrome P-450 3A (CYP3A) gene… CONTINUE READING


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