Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.

@article{MeinholdHeerlein2001ExpressionAP,
  title={Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer.},
  author={Ivo Meinhold-Heerlein and Frank Stenner-Liewen and Heike Liewen and Shinichi Kitada and Maryla Krajewska and Stan Stanislaw Krajewski and Juan Marcelo Zapata and Anne P Monks and Dominic A. Scudiero and Thomas Bauknecht and John C. Reed},
  journal={The American journal of pathology},
  year={2001},
  volume={158 4},
  pages={
          1335-44
        }
}
Fas-associated phosphatase-1 (FAP-1) is a protein-tyrosine phosphatase that binds the cytosolic tail of Fas (Apo1, CD95), presumably regulating Fas-induced apoptosis. Elevations of FAP-1 protein levels in some tumor cell lines have been correlated with resistance to Fas-induced apoptosis. To explore the expression of FAP-1 in ovarian cancer cell lines and archival tumor specimens, mouse monoclonal and rabbit polyclonal antibodies were generated against a FAP-1 peptide and recombinant FAP-1… CONTINUE READING
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