Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant.

@article{Tachikawa2008ExpressionAP,
  title={Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant.},
  author={Masanori Tachikawa and Jun Fujinawa and Masato Takahashi and Yasuyuki Kasai and Masahiro Fukaya and Kazuhisa Sakai and Maya Yamazaki and Masatoshi Tomi and Masahiko Watanabe and Kenji Sakimura and Tetsuya Terasaki and Ken-Ichi Hosoya},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 3},
  pages={768-78}
}
Little is known about the cerebral distribution and clearance of guanidinoacetate (GAA), the accumulation of which induces convulsions. The purpose of the present study was to identify creatine transporter (CRT)-mediated GAA transport and to clarify its cerebral expression and role in GAA efflux transport at the blood-cerebrospinal fluid barrier (BCSFB). CRT mediated GAA transport with a K(m) value of 269 microM/412 microM which was approximately 10-fold greater than that of CRT for creatine… CONTINUE READING

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