Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle.

@article{Fujimura1999ExpressionAP,
  title={Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle.},
  author={Takao Fujimura and Kouichi Tamura and Takeshi Tsutsumi and Takashi Yamamoto and Kei Nakamura and Yukio Koibuchi and Mamoru Kobayashi and Osamu Yamaguchi},
  journal={The Journal of urology},
  year={1999},
  volume={161 2},
  pages={680-5}
}
PURPOSE To investigate the presence of the beta3-adrenoceptor (beta3-AR) in human and rat detrusor muscle and the usefulness of beta3-AR agonists as drugs for the treatment of urinary frequency. MATERIALS AND METHODS FK175, ethyl [(S)-8-[(R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-6,7,8,9-tetrah ydro-5H-benzocyclohepton-2-yloxy]acetate monohydrochloride monohydrate, was used as a beta3-AR selective agonist. The expression of beta-AR subtypes (beta1-, beta2-, beta3-AR) mRNA was investigated in… CONTINUE READING