Expression and mutational status of c-kit in thymic epithelial tumors.

  title={Expression and mutational status of c-kit in thymic epithelial tumors.},
  author={Iacopo Petrini and Paolo Andrea Zucali and Hye Seung Lee and Marbin A. Pineda and Paul S. Meltzer and Beatriz Walter-Rodriguez and Massimo G Roncalli and Armando Santoro and Yisong Wang and Guiseppe Giaccone},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  volume={5 9},
BACKGROUND Overexpression of c-kit, a tyrosine kinase receptor protein encoded by the protooncogene kit, has been previously reported in thymic epithelial tumors and in other neoplasms such as gastrointestinal stromal tumors, myeloproliferative disorders, melanoma, and seminoma. Mutations in the kit gene have been related to response to imatinib in gastrointestinal stromal tumor and one case report of thymic carcinoma. We studied expression of c-kit in a large retrospective series of thymic… CONTINUE READING


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