Expression and modulation of major histocompatibility antigens on murine primary brain tumor in vitro.

@article{Akbasak1991ExpressionAM,
  title={Expression and modulation of major histocompatibility antigens on murine primary brain tumor in vitro.},
  author={Aytac Akbasak and Edward H. Oldfield and S C Saris},
  journal={Journal of neurosurgery},
  year={1991},
  volume={75 6},
  pages={922-9}
}
Lysis of tumor cells by activated cytotoxic lymphocytes requires their recognition of antigens associated with major histocompatibility complex molecules. The authors studied the constitutive expression of Class I and Class II major histocompatibility complex antigens on mouse brain-tumor cells and the capacity of different cytokines and cytokine combinations to alter this expression in vitro. Cells from the murine glioma 26 (GL26), glioma 261 (GL261), and ependymoblastoma A (EpA) cell lines… CONTINUE READING