Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer

Abstract

Tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor that inhibits plasmin-dependent activation of several metalloproteinases. Downregulation of TFPI-2 could thus enhance the invasive potential of neoplastic cells in several cancers, including lung cancer. In this study, TFPI-2 mRNA was measured using a real-time PCR… (More)
DOI: 10.1038/sj.bjc.6602298

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