Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes.

@article{Oshima2003ExpressionAL,
  title={Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes.},
  author={Yusuke Oshima and Chisa Shukunami and Junichi Honda and K. Nishida and Fumi Tashiro and Jun-Ichi Miyazaki and Yuji Hiraki and Yasuo Tano},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 5},
  pages={1814-23}
}
PURPOSE To explore the role in the eye of tenomodulin (TeM), a chondromodulin (ChM)-I-related glycoprotein, the expression, localization, and antiangiogenic potential of TeM were investigated. METHODS Gene expression and protein localization of TeM in mouse eyes were examined by Northern blot analysis, in situ hybridization, and immunohistochemical analysis. Antiangiogenic function included in the C terminus of TeM and ChM-I was examined in vascular endothelial cells through adenoviral gene… CONTINUE READING