Expression and localization of relaxin family peptide receptor 4 in human spermatozoa and impact of insulin-like peptide 5 on sperm functions.

@article{Yeganeh2017ExpressionAL,
  title={Expression and localization of relaxin family peptide receptor 4 in human spermatozoa and impact of insulin-like peptide 5 on sperm functions.},
  author={Imaneh Shamayeli Yeganeh and Amir Hossein Taromchi and Fatemeh Fadaei Fathabadi and R Nejatbakhsh and Marefat Ghaffari Novin and S Shokri},
  journal={Reproductive biology},
  year={2017},
  volume={17 4},
  pages={
          327-332
        }
}
Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily peptide that interacts with the relaxin family peptide receptor 4 (RXFP4). Numerous recent studies have focused on the functional effects of INSL5 on fat and glucose metabolism. Although there is no evidence that the human sperm may be a candidate target of INSL5, it has been detected in mice testis and sperm. Therefore, the present study sought to analyze the localization and expression of RXFP4 on human sperm and determine… CONTINUE READING