Expression and localization of rat NBC4c in liver and renal uroepithelium.

  title={Expression and localization of rat NBC4c in liver and renal uroepithelium.},
  author={Natalia Abuladze and Alexander Pushkin and Sergei F. Tatishchev and Debra K Newman and Pakan Sassani and Ira Kurtz},
  journal={American journal of physiology. Cell physiology},
  volume={287 3},
Previous studies provided functional evidence for electrogenic Na(+)-HCO(3)(-) cotransport in hepatocytes and in intrahepatic bile duct cholangiocytes. The molecular identity of the transporters mediating electrogenic sodium-bicarbonate cotransport in the liver is currently unknown. Of the known electrogenic Na(+)-HCO(3)(-) cotransporters (NBC1 and NBC4), we previously showed that NBC4 mRNA is highly expressed in the liver. In the present study, we performed RT-PCR, immunoblotting, and… CONTINUE READING


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