Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

@article{Koenig2005ExpressionAL,
  title={Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.},
  author={J. Frank Koenig and Mark Hartel and Anne T Nies and Marc Eric Martignoni and Jun-chao Guo and Markus W. B{\"u}chler and Helmut Friess and Dietrich Keppler},
  journal={International journal of cancer},
  year={2005},
  volume={115 3},
  pages={359-67}
}
Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux mediated by several transporters of the ABC superfamily. Especially BCRP (ABCG2), MDR1 P-glycoprotein (ABCB1) and members of the MRP (ABCC) family are important in mediating drug… CONTINUE READING
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