Expression and localization of estrogen receptor-beta in murine and human bone.

  title={Expression and localization of estrogen receptor-beta in murine and human bone.},
  author={O N Vidal and L. G. Kindblom and C Ohlsson},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={14 6},
Estrogens have profound effects on bone metabolism. Cellular responses to estrogens are mediated by estrogen receptors (ERs) which belong to the nuclear receptor superfamily. Two estrogen receptors, ERalpha and ERbeta, have been cloned. Previously expression of ERalpha has been shown in osteoblasts. Here we demonstrate that the transcript for ERbeta can be detected in the human osteosarcoma cell lines (MG-63 and SaOS-2) and in cultured human osteoblast-like cells. We also show that ERbeta… CONTINUE READING

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