Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.

@article{Dawson2006ExpressionAL,
  title={Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.},
  author={Louise A Dawson and Norman J. Maitland and P. C. Berry and Anthony J. Turner and Badar A Usmani},
  journal={Experimental biology and medicine},
  year={2006},
  volume={231 6},
  pages={1106-10}
}
Endothelin (ET)-1 can influence cancer invasion and metastasis by exerting an autocrine (epithelial) or paracrine (stromal) influence on growth. ET-1 is generated from big ET-1 by endothelin-converting enzyme (ECE)-1, which has four recognized isoforms, ECE-1a, ECE-1b, ECE-1c, and ECE-1d, differing only in their amino-terminal regions. This study investigated the expression and localization of the ECE-1 isoforms in prostate cancer (PC). The epithelial cell lines used were androgen-sensitive… CONTINUE READING
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