Expression and localization of dystrophin in human cardiac Purkinje fibers.

  title={Expression and localization of dystrophin in human cardiac Purkinje fibers.},
  author={Roger D. Bies and Diane Friedman and Robert Roberts and M. Benjamin Perryman and C. Thomas Caskey},
  volume={86 1},
BACKGROUND Mutations in the dystrophin gene produce clinical manifestations of disease in heart, brain, and skeletal muscle in patients with Duchenne and Beckers muscular dystrophy (DMD/BMD). Conduction disturbances and heart block contribute to cardiac decompensation in these patients, which suggests an important role for dystrophia in the cardiac conduction system. We therefore examined the messenger RNA (mRNA) expression and protein localization of dystrophin in normal human cardiac Purkinje… CONTINUE READING


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