Expression and localization of acetylcholinesterase at the neuromuscular junction.

@article{Rotundo2003ExpressionAL,
  title={Expression and localization of acetylcholinesterase at the neuromuscular junction.},
  author={Richard L. Rotundo},
  journal={Journal of neurocytology},
  year={2003},
  volume={32 5-8},
  pages={743-66}
}
Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ). AChE was the first protein localized to the NMJ, in the 1930s, and its local expression shown to be regulated by the motoneuron in 1937. By the late 1940s a histochemical procedure was developed to visualize the enzyme at synapses, opening up a new era in the… CONTINUE READING

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