Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

@article{Anderson2007ExpressionAL,
  title={Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.},
  author={Garret R Anderson and Rafael Luj{\'a}n and A. A. Semenov and Marco Pravetoni and Ekaterina N Posokhova and Joseph H Song and Vladimir N. Uversky and C Chen and Kevin Wickman and Kirill A Martemyanov},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 51},
  pages={14117-27}
}
A member of regulator of G-protein signaling family, RGS9-2, is an essential modulator of signaling through neuronal dopamine and opioid G-protein-coupled receptors. Recent findings indicate that the abundance of RGS9-2 determines sensitivity of signaling in the locomotor and reward systems in the striatum. In this study we report the mechanism that sets the concentration of RGS9-2 in vivo, thus controlling G-protein signaling sensitivity in the region. We found that RGS9-2 possesses specific… CONTINUE READING