Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis.

@article{Gut2001ExpressionAL,
  title={Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis.},
  author={Andr{\'e} Gut and Csaba Kir{\'a}ly and Mitsunori Fukuda and Katsuhiko Mikoshiba and Claes B Wollheim and Jessica Christine Lang},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 9},
  pages={1709-16}
}
Exocytosis of insulin containing Large Dense Core Vesicles (LDCVs) from pancreatic beta-cells and derived cell lines is mainly controlled by Ca(2+). Several lines of evidence have demonstrated a role of the Ca(2+)- and phospholipid-binding protein synaptotagmin (syt) in this event. Synaptotagmins form a large protein family with distinct affinities for Ca(2+) determined by their two C(2) domains (C(2)A/B). Except for the well-characterized isoforms I and II, their role is still unclear. We have… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…