Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells.

@article{Peralta2011ExpressionAK,
  title={Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells.},
  author={O A Peralta and William R. Huckle and Willard H Eyestone},
  journal={Differentiation; research in biological diversity},
  year={2011},
  volume={81 1},
  pages={68-77}
}
The mammalian cellular prion protein (PrP(C)) is a highly conserved glycoprotein that may undergo conversion into a conformationally altered isoform (scrapie prion protein or PrP(Sc)), widely believed to be the pathogenic agent of transmissible spongiform encephalopathies (TSEs). Although much is known about pathogenic PrP conversion and its role in TSEs, the normal function of PrP(C) is poorly understood. Given the abundant expression of PrP(C) in the developing mammalian CNS and the spatial… CONTINUE READING
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Developmental expression of the cellular prion protein in elongating axons

  • N. Sales, R. Hassig, +5 authors L. Moya
  • Eur. J. Neurosci
  • 2002
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