Expression and in vitro modification of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor in human myeloma cells.

@article{Otsuki2001ExpressionAI,
  title={Expression and in vitro modification of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor in human myeloma cells.},
  author={Takemi Otsuki and O. Yamada and Junichi Kurebayashi and Haruko Sakaguchi and Kenichiro Yata and Masako Uno and Takashi Oka and Yoshihito Yawata and Ayako Ueki},
  journal={Leukemia & lymphoma},
  year={2001},
  volume={41 3-4},
  pages={397-409}
}
To elucidate the role of PTHrP in myeloma, we examined the expression levels of PTHrP and its receptor in human myeloma cell lines and clinical specimens from 13 myeloma cases. In vitro modification of PTHrP expression and production induced by TGF-beta and PMA in PTHrP expressing myeloma cell lines was also investigated. PTHrP expression was detected in six out of seven myeloma cell lines with an inverse correlation with the expression of its receptor, and in 10 out of 13 clinical specimens in… CONTINUE READING