Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain

@article{Aono2006ExpressionAI,
  title={Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain},
  author={Sachiko Aono and Yoshihito Tokita and Yoko Yasuda and Kanako Hirano and Shinobu Yamauchi and Takuya Shuo and Fumiko Matsui and Hiroomi Keino and Akiko Kashiwai and Noriko Kawamura and Atsuyoshi Shimada and Masao Kishikawa and Mitsuoki Asai and Atsuhiko Oohira},
  journal={Journal of Neuroscience Research},
  year={2006},
  volume={83}
}
Neuroglycan C (NGC) is a transmembrane chondroitin sulfate proteoglycan with an EGF module. We studied the expression of NGC in the human brain, mainly in the hippocampus, and confirmed some observations by conducting experiments using rat brain. In humans, NGC mRNA was expressed exclusively in the brain, especially in the immature brain. The telencephalon, including the hippocampus and neocortex, showed strong mRNA expression. NGC was immunolocalized to neuropils in the hippocampus and… 
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14 Citations
Background Citations
4
Methods Citations
2
Results Citations
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14 Citations

Citation Type

Citation Type

Ectodomain shedding of neuroglycan C, a brain‐specific chondroitin sulfate proteoglycan, by TIMP‐2‐ and TIMP‐3‐sensitive proteolysis
TLDR
Both EGF‐like and neurite outgrowth‐promoting activity of the NGC ectodomain may be regulated by this proteolytic processing.
Neuroglycan C, A Brain-Specific Chondroitin Sulfate Proteoglycan, Interacts with Pleiotrophin, A Heparin-Binding Growth Factor
TLDR
Results suggest that NGC interacts with PTN, and pleiotrophin bound to both chondroitin sulfate-bearing NGC and chONDroitinase-treated NGC prepared from the neonatal rat brain.
Neuroglycan C Is a Novel Midkine Receptor Involved in Process Elongation of Oligodendroglial Precursor-like Cells*
TLDR
It is concluded that neuroglycan C is a novel component of midkine receptors involved in process elongation in undifferentiated bipolar CG-4 cells.
Chondroitin sulfate proteoglycans in the brain.
Differential neuroglycan C expression during retinal degeneration in Rpe65−/− mice
TLDR
During retinal degeneration in Rpe65−/− mice, NGC expression is induced in the neural retina, but not in the RPE, where NGC is expressed at highest levels.
Identification and Functions of Chondroitin Sulfate in the Milieu of Neural Stem Cells*
TLDR
Results suggest that brain-specific chondroitin sulfate proteoglycans are involved in the proliferation of neural stem cells as a group of cell microenvironmental factors.
Opposing functions of chondroitin sulfate and heparan sulfate during early neuronal polarization
On the Modulatory Roles of Neuregulins/ErbB Signaling on Synaptic Plasticity
TLDR
Current evidence points to a central role of NRGs/ErbB receptors in controlling glutamatergic LTP/LTD and GABAergic LTD at hippocampal CA3–CA1 synapses, thus supporting that NRGs or ErbB signaling is essential for proper brain functions, cognitive processes, and complex behaviors.
Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5
TLDR
No protective effect or any involvement of Cspg5 in disease progression was identified and no retinal phenotype was detected in the late postnatal and adult CspG5−/− mice, when compared to the wild-type mice.
Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights
TLDR
This review has compiled the current knowledge about the structure and function of important ECM molecules in the brain and their proteolytic remodeling by matrix metalloproteinases and other enzymes, highlighting the special structures they form.
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References

SHOWING 1-10 OF 23 REFERENCES
Genomic Organization and Expression Pattern of Mouse Neuroglycan C in the Cerebellar Development*
TLDR
Western blot analysis demonstrated that, although N GC in the immature cerebellum existed in a proteoglycan form, most NGC in the mature Cerebellum did not bear chondroitin sulfate chain(s), indicating that NGC is a typical part-time proteoglyca.
Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module
Phosphorylation of Neuroglycan C, a Brain-specific Transmembrane Chondroitin Sulfate Proteoglycan, and Its Localization in the Lipid Rafts*
TLDR
This is the first report to demonstrate that NGC can be phosphorylated both intracellularly and pericellularly, and the findings suggest that a kinase with a specificity similar to that of casein kinase II is responsible for the NGC ectodomain phosphorylation.
Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation.
TLDR
The results show spatiotemporal expression patterns of NGC, and suggest that it plays a role in the formation of neural networks in retinal development.
Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C*
TLDR
The CS glycosylation was not necessary for intracellular trafficking of NGC to the cell surface at least in Neuro 2a cells, suggesting that the addition of CS chains to the NGC core protein is regulated in a manner different from that of other CS proteoglycans.
Developmental changes in the biochemical and immunological characters of the carbohydrate moiety of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan
TLDR
Findings indicate that the structure of the carbohydrate moiety of NGC is developmentally regulated, and differs from those of neurocan and phosphacan, and may be partly implicated in the modulation of neuronal cell recognition during brain development.
Neuroglycan C, a Novel Membrane-spanning Chondroitin Sulfate Proteoglycan That Is Restricted to the Brain (*)
TLDR
The sequence of the proteoglycan did not exhibit significant homology to any other known protein, indicating that the proteglycan, designated neuroglycan C, is a novel integral membrane proteogly can.
Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development.
TLDR
This review mainly summarizes recent studies on the involvement of these three classes of proteoglycan in cell-cell and cell-substratum interactions during the brain development.
Regulation of Neuregulin Expression in the Injured Rat Brain and Cultured Astrocytes
TLDR
The results suggest that the enhancement of neuregulin expression at injured sites is induced, at least in part, by elevation in intracellular cAMP levels and/or a protein kinase C signaling pathway.
Brain development and multiple molecular species of proteoglycan
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