Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells.

@article{Minuesa2007ExpressionAF,
  title={Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells.},
  author={Gerard Minuesa and Sergi Purcet and Itziar Erkizia and M{\'i}riam Molina-Arcas and M. Bardaj{\'i} Bofill and Nuria Izquierdo-Useros and Fco Javier Casado and Bonaventura Clotet and Marçal Pastor-Anglada and Javier Martinez-Picado},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={324 2},
  pages={
          558-67
        }
}
Almost all drugs used in anti-human immunodeficiency virus (HIV)-1 and anticancer therapies require membrane proteins to get into the cell to develop their proper activity. Nevertheless, little is known regarding the expression and activity of specific carriers involved in the uptake of these drugs in immune cells. Here, we assessed the mRNA levels, protein expression profile, and activity of the gene families SLC28 (coding for concentrative nucleoside transporters, hCNT1-3), SLC29… CONTINUE READING

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