Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells.

@article{HeroldMende1999ExpressionAF,
  title={Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells.},
  author={Christel C. Herold-Mende and Hans Herbert Steiner and Thomas Andl and Dr. med. U. N. Riede and Annette Buttler and Christoph J. Rei\sser and Norbert E. Fusenig and Margareta M. Mueller},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1999},
  volume={79 12},
  pages={1573-82}
}
Vascular endothelial growth factor (VEGF) is one of the key factors in tumor neoangiogenesis, acting through its receptors KDR (VEGFR-2) and fit-1 (VEGFR-1) expressed on endothelial cells. Our data demonstrate that VEGFR-1 and to a lesser extent VEGFR-2 are expressed in a number of human tumor tissues and derived cells in culture. VEGFR-1 protein is… CONTINUE READING