Expression and functional significance of tumor necrosis factor receptors in human myocardium.

@article{TorreAmione1995ExpressionAF,
  title={Expression and functional significance of tumor necrosis factor receptors in human myocardium.},
  author={Guillermo Torre-Amione and Samir Kapadia and Jong-Kook Lee and Roger D. Bies and Russell M. Lebovitz and Douglas L. Mann},
  journal={Circulation},
  year={1995},
  volume={92 6},
  pages={1487-93}
}
BACKGROUND Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine with potent negative inotropic properties, is elaborated in septic shock, acute myocarditis, reperfusion injury, and congestive heart failure. TNF-alpha acts by binding to two specific receptors: TNFR1 and TNFR2. However, neither the presence nor the significance of TNF receptors has been studied in the adult mammalian heart. METHODS AND RESULTS In the present study, we showed that the adult heart expresses mRNA… CONTINUE READING