Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes.

  title={Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes.},
  author={Hongwei Qin and Sandrine A. Niyongere and Sun Jung Lee and Brandi J. Baker and Etty Nadia Benveniste},
  journal={Journal of immunology},
  volume={181 5},
Astrocytes play a number of important physiological roles in CNS homeostasis. Inflammation stimulates astrocytes to secrete cytokines and chemokines that guide macrophages/microglia and T cells to sites of injury/inflammation. Herein, we describe how these processes are controlled by the suppressor of cytokine signaling (SOCS) proteins, a family of proteins that negatively regulate adaptive and innate immune responses. In this study, we describe that the immunomodulatory cytokine IFN-beta… CONTINUE READING


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