Expression and functional roles of Smad1 and BMPR-IB in glioma development.

  title={Expression and functional roles of Smad1 and BMPR-IB in glioma development.},
  author={Shuang Jiang Liu and Zengmin Tian and Feng Yin and Peng Zhang and W Yanrui and Xuefeng Ding and Haitao Wu and Yan Wu and Xiaozhong Peng and Jiangang Yuan and Boqin Qiang and Wen-hong Fan and Ming Fan},
  journal={Cancer investigation},
  volume={27 7},
Here we report the negative correlation of phosphorylation of Smad1 and BMPR-IB expression with the development of human glioma. Western blot analysis showed that expression of both phospho-Smad1/5/8 and BMPR-IB were decreased in malignant glioma tissues compared with normal brain tissues. Kaplan-Meier survival curves revealed that lower expression ratio of phospho-Smad1/5/8 to Smad1 expression significantly correlates with poor patient survival. Transient transfection of BMPR-IB activates… CONTINUE READING

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