Expression and functional role of Nav1.9 sodium channel in cartwheel cells of the dorsal cochlear nucleus.

@article{Yan2015ExpressionAF,
  title={Expression and functional role of Nav1.9 sodium channel in cartwheel cells of the dorsal cochlear nucleus.},
  author={Zhiyu Yan and Yanjun Xu and Min-yi Liang and Xiaowei Ren},
  journal={Molecular medicine reports},
  year={2015},
  volume={11 3},
  pages={
          1833-6
        }
}
In the central auditory system, cartwheel cells (CWCs) are a group of interneurons in the dorsal cochlear nucleus (DCN). While other DCN neurons respond to stimuli with a simple discharge pattern of single action potentials (SAPs), CWCs respond with complex action potentials (CAPs), consisting of SAPs superimposed on a slow depolarization. The CAPs in CWCs may participate in various auditory or non‑auditory signaling processing but its intrinsic mechanisms are largely unknown. In the present… 
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SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves
TLDR
A role of Nav1.9 in regulating the function of ribbon synapses and the auditory nerves is suggested in regulating and controlling cochlear synaptopathy in mice knockout with SCN11A gene deletion.

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