Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.

@article{Ghosh2013ExpressionAF,
  title={Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.},
  author={Chaitali Ghosh and Mohammed Shadat Hossain and Vikram Puvenna and Jorge Martinez-Gonzalez and Andreas Alexopolous and Damir Janigro and Nicola De Marchi},
  journal={Epilepsia},
  year={2013},
  volume={54 9},
  pages={1562-70}
}
PURPOSE Brain drug bioavailability is regulated by the blood-brain barrier (BBB). It was recently suggested that cytochrome P450 (CYP) enzymes could act in concert with multidrug transporter proteins to regulate drug penetration and distribution into the diseased brain. The possibility that phase II metabolic enzymes could be expressed in the epileptic brain has been not evaluated. Phase II enzymes are involved in the metabolism of common antiepileptic drugs (AEDs). METHODS Phase II enzyme… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…