Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells.

@article{Reddy1999ExpressionAF,
  title={Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells.},
  author={J. Ashok Vardhan Reddy and Laura S. Haneline and Edward F Srour and Aśok C. Antony and David W Clapp and Philip S Low},
  journal={Blood},
  year={1999},
  volume={93 11},
  pages={3940-8}
}
We have investigated the expression and functional competence of folate receptor (FR) isoforms on human hematopoietic cells. Using immunofluorescence and reverse transcriptase-polymerase chain reaction (RT-PCR) methodology, we find that a substantial fraction of low-density mononuclear and CD34(+) cells express both the beta and gamma isoforms of FR. The alpha isoform of FR (the form most commonly found on cancer cells) was surprisingly absent from all hematopoietic cells examined. Compared… CONTINUE READING

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