Expression and functional characterization of CFTR in mast cells.

  title={Expression and functional characterization of CFTR in mast cells.},
  author={Marianna Kulka and Mark Gilchrist and Marek Duszyk and A Dean Befus},
  journal={Journal of leukocyte biology},
  volume={71 1},
Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows that rat-cultured mast cells (RCMC) and peritoneal mast cells (PMC) contain mRNA for the cystic fibrosis transmembrane conductance regulator (CFTR), an important chloride channel… CONTINUE READING


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