Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis.

@article{Yu2007ExpressionAF,
  title={Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis.},
  author={Qi T. Yu and Masayuki Saruta and Armine Avanesyan and Phillip R. Fleshner and Alison H Banham and Konstantinos Antonios Papadakis},
  journal={Inflammatory bowel diseases},
  year={2007},
  volume={13 2},
  pages={
          191-9
        }
}
BACKGROUND CD4+CD25+ regulatory T cells (TR) can prevent or treat experimental murine colitis but little is known about their potential role in human inflammatory bowel disease (IBD). FOXP3 is a transcription factor that plays a critical role in the development and function of CD4+CD25+ TR. The aim of this study was to examine the presence and functional characteristics of TR cells in colonic lymphoid tissues in patients with ulcerative colitis (UC). METHODS FOXP3 expression was assessed by… CONTINUE READING

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