Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene.

@article{Lin1998ExpressionAF,
  title={Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene.},
  author={Xu Li-n and Lin Gan and William H. Klein and Dan Wells},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={248 3},
  pages={
          738-43
        }
}
Hereditary multiple exostoses (EXT) is a genetically heterogeneous, autosomal dominant skeletal disorder. The gene for EXT1 maps to human chromosome 8q24.1 and encodes an evolutionary conserved protein that is a member of a multigene family. The mouse homolog of human EXT1 protein is 99% similar to its human counterpart. Here, we present the expression profiles of the mouse EXT1 gene. EXT1 mRNA is initially expressed at 6.5 days post-coitum (d.p.c.), which coincides with gastrulation of the… CONTINUE READING

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