Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

@article{Hegmann1992ExpressionAF,
  title={Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.},
  author={E J Hegmann and H. C Bauer and Robert S. Kerbel},
  journal={Cancer research},
  year={1992},
  volume={52 24},
  pages={6969-75}
}
Analysis of a panel of endothelial cells passaged between 5 and 25 times and derived from various organs and species demonstrated that murine and porcine cerebral capillary endothelial cells actively excluded the fluorescent dye rhodamine 123, a substrate of P-glycoprotein. In addition, rhodamine 123 accumulation could be enhanced by the multidrug resistance chemosensitizer verapamil, known to reduce P-glycoprotein-mediated drug efflux. Cloned murine and porcine cerebral capillary endothelial… CONTINUE READING
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