Expression and function of the leucine zipper protein Par-4 in apoptosis.

  title={Expression and function of the leucine zipper protein Par-4 in apoptosis.},
  author={Stephen F. Sells and Sang Seop Han and S Muthukkumar and N G Maddiwar and Ricky Johnstone and Erwin R. Boghaert and David Gillis and Gang Liu and P Nair and S Monnig and Paola Collini and Mark P. Mattson and Vikas P Sukhatme and Stephen G. Zimmer and David P. Wood and J W Mcroberts and Yang Shi and Vivek M. Rangnekar},
  journal={Molecular and cellular biology},
  volume={17 7},
The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carboxy terminus. We have recently shown that the Par-4 protein binds, via its leucine zipper domain, to… CONTINUE READING
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Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells

  • S. F. Sells, D. P. Wood, +6 authors V. M. Rangnekar
  • Cell Growth Differ
  • 1994
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