Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis.

@article{Cummings1999ExpressionAF,
  title={Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis.},
  author={C. James Cummings and Tyler P. Martin and Charles W Frevert and Junming Quan and Venus A. Wong and Steven M. Mongovin and Tonja R. Hagen and Kenneth P. Steinberg and Richard C. Goodman},
  journal={Journal of immunology},
  year={1999},
  volume={162 4},
  pages={2341-6}
}
Neutrophils (polymorphonuclear neutrophils; PMN) and a redundant system of chemotactic cytokines (chemokines) have been implicated in the pathogenesis of the acute respiratory distress syndrome in patients with sepsis. PMN express two cell surface receptors for the CXC chemokines, CXCR1 and CXCR2. We investigated the expression and function of these receptors in patients with severe sepsis. Compared with normal donors, CXCR2 surface expression was down-regulated by 50% on PMN from septic… CONTINUE READING
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