Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

  title={Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.},
  author={Daniel P Poole and Caroline Godfrey and Fiore Cattaruzza and Graeme S Cottrell and Jacob G Kirkland and Juan Carlos Pelayo and Nigel W Bunnett and Carlos U. Corvera},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  volume={22 7},
  pages={814-25, e227-8}
BACKGROUND Bile acids (BAs) regulate cells by activating nuclear and membrane-bound receptors. G protein coupled bile acid receptor 1 (GpBAR1) is a membrane-bound G-protein-coupled receptor that can mediate the rapid, transcription-independent actions of BAs. Although BAs have well-known actions on motility and secretion, nothing is known about the localization and function of GpBAR1 in the gastrointestinal tract. METHODS We generated an antibody to the C-terminus of human GpBAR1, and… CONTINUE READING


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