Expression and function of the Trypanosoma brucei major surface protease (GP63) genes.

@article{Lacount2003ExpressionAF,
  title={Expression and function of the Trypanosoma brucei major surface protease (GP63) genes.},
  author={Douglas J Lacount and Amy E Gruszynski and Paul M Grandgenett and James D Bangs and J. E. Donelson},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 27},
  pages={24658-64}
}
The genome of the African trypanosome Trypanosoma brucei (Tb) contains at least three gene families (TbMSP-A, -B, and -C) encoding homologues of the abundant major surface protease (MSP, previously called GP63), which is found in all Leishmania species. TbMSP-B mRNA occurs in both procyclic and bloodstream trypanosomes, whereas TbMSP-A and -C mRNAs are detected only in bloodstream organisms. RNA interference (RNAi)-mediated gene silencing was used to investigate the function of TbMSP-B protein… CONTINUE READING